MIKAI RAG

Any blood test to predict the anoxic brain injury?

**Neurological Biomarkers:** – **Neuron-Specific Enolase (NSE):** – Elevated levels correlate with poor outcomes in anoxic brain injury. – Rationale: NSE is released from damaged neurons; levels >33 µg/L at 48–72 hours post-injury suggest poor prognosis. –

**S100B Protein:** – Elevated levels may indicate blood-brain barrier disruption. – Rationale: Levels >0.1 µg/L at 24–48 hours post-injury are associated with worse outcomes. –

**Glial Fibrillary Acidic Protein (GFAP):** – Elevated levels indicate astrocyte damage. – Rationale: Levels >1.5 ng/mL at 24–72 hours post-injury correlate with poor prognosis. –

**Inflammatory Markers:** –

**C-Reactive Protein (CRP) and Interleukin-6 (IL-6):** – Elevated levels may reflect systemic inflammation post-anoxia. – Rationale: Higher levels are associated with increased mortality, but not specific to anoxic injury alone. –

**Electrolytes and Metabolic Markers:** – **Lactate and Creatinine Kinase (CK):** – Elevated lactate suggests tissue hypoxia; CK may indicate muscle damage (e.g., from seizures). – Rationale: Useful for assessing systemic response but not specific to brain injury. –

**Limitations:** – No single biomarker is definitive; clinical correlation with neurological exam and imaging is essential. – Therapeutic hypothermia may alter biomarker kinetics, requiring cautious interpretation.